痉挛性发声障碍的病理学症，发病解雇研究论文被发表在 国际学术刊物上 - 最新研究活动

艺颂嗓音中心金亨泰院长发表的痉挛性发声障碍原因的研究论文，被国际学术期刊-耳鼻喉知名学术杂志（Acta Oto-Laryngologica）收藏并发表。


这篇研究论文是金亨泰院长在Catholic 医科大学 圣母医院担任教授时施行研究的，通过严格过审核，于2005年被收藏。

论文题目: Neuroimmunological activation of the afferent laryngeal 

neuronal circuit in experimentally induced laryngeal inflammation.

论文指名 : Acta Oto-laryngologica, 2005; 125: 184-190

提要 Abstract: 

Conclusions: These results show that laryngeal inflammatory reactions may induce the 
expression of proinflammatory cytokines along the afferent laryngeal circuit and in nuclei 
associated with the HPA axis. Local laryngeal inflammation may induce functional and 
physiologic alterations in the laryngeal neural system via neuroimmunologic reactions.

Objective: Idiopathic laryngeal disorders associated with various neurologic conditions 
such as spasmodic dysphonia, idiopathic vocal fold paralysis and sudden infant death 
syndrome are causally related to upper respiratory tract infections, and it can be 
speculated that these disorders result in neurophysiologic alterations. The goal of this 
study was to identify the neurophysiologic effect on the central nervous system 
of local inflammatory alterations in the larynx.

Material and methods: The expression of c-fos and IL-1β was identified after injecting 
saline solution, 10 μg of lipopolysaccharide or 100 μg of lipopolysaccharide into the larynx of 12 rats.

Results: The inflammatory cytokine IL-1β was mainly expressed in the inferior olivary 
nucleus and raphe nucleus, which are associated with the hypothalamic-pituitary-
adrenal (HPA) axis. IL-1β expression was also found in the nuclei of afferent nervous 
pathways of the superior laryngeal nerve, such as the nucleus tractus solitarius, 
nucleus ambiguus, lateral reticular nucleus, magnocellular reticular nucleus 
and paragigantocellular reticular nucleus.